I've encoutendred today a problem with Backup Exec 2010 after applied updates (HotFix 144101, 148347, 15309, 147674)
These errors were present In Windows application event log :
Event ID 58368 : Port 3527 must be available for the central administration server to communicate with the managed media server.
Event ID 57802 : The Backup Exec Server Service did not start. An internal error (-22) occurred in object 11.
This bug was referenced by Symantec : http://www.symantec.com/business/support/index?page=content&id=TECH68932
So, as they say : Open task manager and locate the LUGETUPDATES.exe process. If LUGETUPDATES.exe is present and running, end the process.